TTN Associated with Asthma

TTN Associated with Asthma

Liem JJ, Huq SI, Ekuma O, et al. Transient Tachypnea of the Newborn May Be an Early Clinical Manifestation of Wheezing Symptoms. J Pediatr (July 2007); 151: 29-33. Full Text | Full-Text PDF (166 KB)

Objective. To determine risk factors associated with transient tachypnea of the newborn (TTN) and whether TTN is associated with development of wheezing syndromes in early life.

Study design. The Population Health Research Data Repository at the Manitoba Centre for Health Policy is a healthcare administrative and prescription database. Data for children diagnosed with a wheezing syndrome (defined as bronchiolitis, acute bronchitis, chronic bronchitis, asthma, or prescription for asthma medication) were obtained. Term children diagnosed with TTN at birth were selected. Cox proportional hazards regression analysis for time to first event of hospitalizations, physician visits, or prescription for an asthma medication up to 7 years of age were calculated. The hazard ratios for wheezing in a child with TTN were compared with healthy newborns.

Results. Twelve thousand seven hundred sixty-three children were born at term in 1995 and currently live in the province of Manitoba. Of these children, 308 (2.4%) developed TTN. Maternal asthma, birth weight ≥4500 g, male sex, and urban location were risk factors for development of TTN. Infants with TTN at birth were at significantly increased risk of a wheezing disorder in childhood (adjusted hazard ratio [HR] = 1.17, 95% CI 1.02-1.34).

Conclusion. TTN is associated with development of wheezing syndromes in childhood.

Comments: The etiology of Transient Tachypnea of the Newborn is clearly multifactorial. Predisposing factors include C-section delivery (OR=3.63); birth weight > 4.5kg (OR=1.85) and maternal asthma (OR=1.48). It now seems clear that infants with TTN are at higher risk for asthma-like syndromes, even if there is no history of maternal asthma. ABK

Date: 04 Jul 2007
Time: 21:27:26

How long does this association last? In other words, is this just a pediatric asthma, in which the child outgrows in the first 7-10 years, or does it last longer--even into adulthood? What is the typical age for outgrowth?

UserName: Kristin Mack, RNC
Institution: Medical Center of Plano, Texas, US
telephone: 214-802-0189
email: kristin.mack101@tx.rr.com

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