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Andrew B. Kairalla MD, Editor

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Epidural Fevers and Antibiotics

Maternal epidural analgesia and rates of maternal antibiotic treatment in a low-risk nulliparous population.  Goetzl L, Cohen A, Lang JM, et al. J Perinatol. 2003 Sep;23(6):457-61.

Background: Epidural analgesia is associated with an increased rate of fever in prospective randomized trials. While the evidence suggests that epidural fever is not infectious, epidural analgesia has been associated with increased rates of antibiotic use, the indications that prompt treatment have not been examined.

Methods: We analyzed 1235 nulliparous women with singleton term pregnancies presenting in labor with a temperature of < 99.5 degrees F. Antibiotic use during labor was categorized by indication.

Results: A total of 59.6% of women received epidural analgesia. The rate of antibiotic use was significantly higher in women receiving epidural analgesia (28 vs 10.8%). After adjusting for confounders using logistic regression, epidural analgesia was associated with a relative risk of 2.6 (95% CI 2.0, 3.4) for antibiotic treatment. The majority of the increased risk was due to significantly higher rates of antibiotic treatment for presumed chorioamnionitis (9.0 vs 0.4%) in the epidural analgesia group.

Conclusion: Epidural-related fever results in excess maternal antibiotic treatment for presumed chorioamnionitis.


Comment.  Epidural fevers are common during labor, and are usually not associated with infection. Many obstetricians are inclined to “cover” with antibiotics whenever fever with labor is present.  If asked for a reason for the antibiotic treatment, the usual response is “possible or suspected chorioamnionitis” (due to fever).  The recent CDC guidelines for prevention of early-onset group B Strep infections state that infants born to mothers treated with antibiotics during labor for suspected chorioamnionitis should have a sepsis evaluation and treatment with IV antibiotics pending culture results (see 3-053).  This poses a therapeutic dilemma for pediatricians and neonatologists.  On one hand, we would like to avoid doing unnecessary laboratory studies and antibiotic treatment for healthy-appearing term babies because their mother had a low-grade epidural fever and was “covered” with antibiotics.  On the other hand, if we elect to simply observe these infants without doing labs or antibiotic treatment, we assume the liability of practicing outside of an established CDC and AAP practice guideline.  It would be helpful if our obstetric colleagues would reserve to diagnosis of “suspected chorioamnionitis” for patients with the complete clinical picture suggestive of that diagnosis.  In addition to fever, this might include uterine tenderness, increased uterine irritability, cloudy or foul-smelling amniotic fluid, and fetal tachycardia.  For patients with only a low-grade fever after epidural anesthesia, let’s just call it a "probable epidural fever” ABK.

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