NeoNotes Journal Club
Andrew B. Kairalla MD, Editor

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New GBS Prevention Guidelines
Prevention of Perinatal Group B Streptococcal Disease: Revised Guidelines from CDC.
 Schrag S, Gorwitz R, Fultz-Butts K, et al.  MMWR 2002; 51(R11):1-22.

Future Prevention Strategies

Ø       GBS Vaccines - Serotype-specific antibodies to GBS capsular polysaccharide have been shown to protect against disease. Phase 1 and 2 clinical trials among healthy, nonpregnant adults of monovalent protein-conjugate vaccines containing capsular polysaccharide antigens of GBS disease-associated serotypes have shown these vaccines to be well tolerated and immunogenic.  Hopefully, a GBS vaccine that eliminates maternal colonization with this organism will be available soon.

Ø       Rapid Tests to Detect GBS - A new rapid PCR assay for GBS has been developed.  This test was 97% sensitive and 100% specific when compared with cultures.  (See 3-046 on our web site for more information).
 

 

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