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Preterm Rupture of Membranes
Editor’s Note:
The topic of Preterm Premature Rupture of Membranes (PPROM) was the subject of the Dec 2001 issue of Clinics in Perinatology. Since neonatologists are occasionally called upon to advise obstetricians or counsel families with this condition, I felt that an update on the latest recommendations might be helpful. ABKAmniopatch for PPROM
Quintero RA. Clinics in Perinatology (Dec 2001); 28:861-76.
This paper described the Amniopatch technique for treating iatrogenic (after amniocentesis) PPROM. Candidates for this technique had iatrogenic PPROM at 16-24 weeks gestation and had continued leakage of fluid after 1 week of bed rest and IV antibiotic therapy. The Amniopatch treatment consisted of intra-amniotic infusion of platelets followed by cryoprecipitate. The dose of platelets was limited to 0.5 units because larger doses of platelets were associated with fetal demise. The technique was successful in sealing the leak in 6/7 patients with gross leaking of fluid after amniocentesis or fetoscopy. Five of these patients (57%) had a successful pregnancy outcome.
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