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Preterm Rupture of Membranes
Editor’s Note:
The topic of Preterm Premature Rupture of Membranes (PPROM) was the subject of the Dec 2001 issue of Clinics in Perinatology. Since neonatologists are occasionally called upon to advise obstetricians or counsel families with this condition, I felt that an update on the latest recommendations might be helpful. ABKAntibiotics and PPROM
Ehrenberg HM and Mercer BM. Clinics in Perinatology (Dec 2001); 28:807-815.
Although the underlying pathophysiology of PPROM remains largely undefined, subclinical infection has been implicated both in the mechanism of membrane rupture, and in the resultant neonatal morbidity. The use of maternal systemic antibiotics reduces both the maternal and the neonatal morbidity in the expectant management of PPROM. Although concern persists over the development of resistant strains of organisms involved with neonatal sepsis, current data support the use of antibiotics in this setting.
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