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Presented at High Frequency Ventilation Conference, Snowbird Utah - April 4-9, 2000
Early High Frequency Oscillatory Ventilation Optimization Strategy. Nona J, Nogueira M, Virella D, et al. Lisbon, Portugal.
This study compares Early HFOV (first ventilator, before surfactant administration) versus HFOV after surfactant administration and a short period of conventional ventilation (about 2 hours) in premature babies (< 34 weeks) with RDS. Findings included significantly shorter periods of oxygen and ventilator therapy in the early HFOV group. When infants < 29 weeks were analyzed, the early HFOV group had significantly less ventilator and oxygen time, length of stay, chronic lung disease, ROP, and mortality.
Comment. The study was not randomized, and utilized a retrospective control group. A prospective randomized clinical trial is needed to confirm these observations.
Andrew B. Kairalla MD